Host proteostasis modulates influenza evolution.
Ontology highlight
ABSTRACT:
SUBMITTER: Phillips AM
PROVIDER: S-EPMC5614556 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Host proteostasis modulates influenza evolution.
Phillips Angela M AM Gonzalez Luna O LO Nekongo Emmanuel E EE Ponomarenko Anna I AI McHugh Sean M SM Butty Vincent L VL Levine Stuart S SS Lin Yu-Shan YS Mirny Leonid A LA Shoulders Matthew D MD
eLife 20170926
Predicting and constraining RNA virus evolution require understanding the molecular factors that define the mutational landscape accessible to these pathogens. RNA viruses typically have high mutation rates, resulting in frequent production of protein variants with compromised biophysical properties. Their evolution is necessarily constrained by the consequent challenge to protein folding and function. We hypothesized that host proteostasis mechanisms may be significant determinants of the fitne ...[more]
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