Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC5614562 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
eLife 20170926
Hepatitis B virus (HBV) infection is a major global health problem. Currently-available therapies are ineffective in curing chronic HBV infection. HBV and its satellite hepatitis D virus (HDV) infect hepatocytes via binding of the preS1 domain of its large envelope protein to sodium taurocholate cotransporting polypeptide (NTCP). Here, we developed novel human monoclonal antibodies that block the engagement of preS1 with NTCP and neutralize HBV and HDV with high potency. One antibody, 2H5-A14, f ...[more]