Specific titin and myomesin domains stimulate myoblast proliferation.
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ABSTRACT:
SUBMITTER: Kravchenko IV
PROVIDER: S-EPMC5614584 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Specific titin and myomesin domains stimulate myoblast proliferation.
Kravchenko Irina V IV Furalyov Vladimir A VA Popov Vladimir O VO
Biochemistry and biophysics reports 20161230
Myofibrillar proteins titin and myomesin stimulated myoblast proliferation as determined by MTT-test and labelled thymidine incorporation in the DNA. Specific Fn type III and Ig-like domains of these proteins were able to exert mitogenic effects as well. Proliferative effect of Fn type III domains was highly sensitive to inhibition of Ca<sup>2+</sup>/calmodulin dependent protein kinase, whereas the effect of Ig-like domains showed greater sensitivity to the inhibition of adenylyl cyclase - cAMP ...[more]
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