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Height and lung cancer risk: A meta-analysis of observational studies.


ABSTRACT: The association between height and lung cancer risk has been investigated by epidemiological studies but the results are inconsistent. This meta-analysis was to evaluate whether the height is associated with lung cancer.We identified relevant articles by searching the MEDLINE and EMBASE databases, and reviewed the reference lists of selected papers. A random effect model was used to calculate summary odds ratios (OR) and relative risk (RR) with 95% confidence intervals (95% CI). Publication bias was estimated using Egger's regression asymmetry test.We included a total 16 studies (15 prospective studies and one case-control study) on adult height and lung cancer risk in the meta-analysis. Overall, per 10-cm height increases were associated with increased risk of lung cancer (RR 1.06; 95% CI 1.03-1.09, I2 = 43.6%).In this meta-analysis, high adult height is related to increased lung cancer risk. Well-designed, large prospective studies are required to obtain a better indication of the relationship.

SUBMITTER: Wang F 

PROVIDER: S-EPMC5614604 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Height and lung cancer risk: A meta-analysis of observational studies.

Wang Fang F   Xu Xingxiang X   Yang Junjun J   Min Lingfeng L   Liang Sudong S   Chen Yong Y  

PloS one 20170926 9


<h4>Background</h4>The association between height and lung cancer risk has been investigated by epidemiological studies but the results are inconsistent. This meta-analysis was to evaluate whether the height is associated with lung cancer.<h4>Methods</h4>We identified relevant articles by searching the MEDLINE and EMBASE databases, and reviewed the reference lists of selected papers. A random effect model was used to calculate summary odds ratios (OR) and relative risk (RR) with 95% confidence i  ...[more]

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