Ontology highlight
ABSTRACT:
SUBMITTER: Ohbuchi A
PROVIDER: S-EPMC5614717 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Ohbuchi Ayako A Kono Mari M Kitagawa Kaihei K Takenokuchi Mariko M Imoto Shion S Saigo Katsuyasu K
Biochemistry and biophysics reports 20170724
Formation of neutrophil extracellular traps (NETs) can perpetuate sterile inflammation; thus, it is important to clarify their pathophysiological characteristics. Free heme, derived via hemolysis, is a major contributor to organ damage, and reportedly induces neutrophil activation as well as reactive oxygen species (ROS) production and NET formation. For this study, we examined hemin (Fe<sup>3+</sup> -protoporphyrin IX)-induced NET formation quantitatively in vitro as well as the effects of oxid ...[more]