Loss of corticospinal tract integrity in early MS disease stages.
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ABSTRACT:
SUBMITTER: Pawlitzki M
PROVIDER: S-EPMC5614727 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Loss of corticospinal tract integrity in early MS disease stages.
Pawlitzki Marc M Neumann Jens J Kaufmann Jörn J Heidel Jan J Stadler Erhard E Sweeney-Reed Catherine C Sailer Michael M Schreiber Stefanie S
Neurology(R) neuroimmunology & neuroinflammation 20170925 6
<h4>Objective</h4>We investigated corticospinal tract (CST) integrity in the absence of white matter (WM) lesions using diffusion tensor imaging (DTI) in early MS disease stages.<h4>Methods</h4>Our study comprised 19 patients with clinically isolated syndrome (CIS), 11 patients with relapsing-remitting MS (RRMS), and 32 age- and sex-matched healthy controls, for whom MRI measures of CST integrity (fractional anisotropy [FA], mean diffusivity [MD]), T1- and T2-based lesion load, and brain volumes ...[more]
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