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A modular design for minor groove binding and recognition of mixed base pair sequences of DNA.


ABSTRACT: The design and synthesis of compounds that target mixed, AT/GC, DNA sequences is described. The design concept connects two N-methyl-benzimidazole-thiophene single GC recognition units with a flexible linker that lets the compound fit the shape and twist of the DNA minor groove while covering a full turn of the double helix.

SUBMITTER: Guo P 

PROVIDER: S-EPMC5616130 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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A modular design for minor groove binding and recognition of mixed base pair sequences of DNA.

Guo Pu P   Paul Ananya A   Kumar Arvind A   Harika Narinder K NK   Wang Siming S   Farahat Abdelbasset A AA   Boykin David W DW   Wilson W David WD  

Chemical communications (Cambridge, England) 20170907 75


The design and synthesis of compounds that target mixed, AT/GC, DNA sequences is described. The design concept connects two N-methyl-benzimidazole-thiophene single GC recognition units with a flexible linker that lets the compound fit the shape and twist of the DNA minor groove while covering a full turn of the double helix. ...[more]

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