Ontology highlight
ABSTRACT:
SUBMITTER: Nakano-Kobayashi A
PROVIDER: S-EPMC5617268 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Nakano-Kobayashi Akiko A Awaya Tomonari T Kii Isao I Sumida Yuto Y Okuno Yukiko Y Yoshida Suguru S Sumida Tomoe T Inoue Haruhisa H Hosoya Takamitsu T Hagiwara Masatoshi M
Proceedings of the National Academy of Sciences of the United States of America 20170905 38
Down syndrome (DS) caused by trisomy of chromosome 21 is the most common genetic cause of intellectual disability. Although the prenatal diagnosis of DS has become feasible, there are no therapies available for the rescue of DS-related neurocognitive impairment. A growth inducer newly identified in our screen of neural stem cells (NSCs) has potent inhibitory activity against dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) and was found to rescue proliferative deficits in T ...[more]