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The 4D nucleome project.

ABSTRACT: The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.

SUBMITTER: Dekker J

PROVIDER: S-EPMC5617335 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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The 4D nucleome project.

Dekker Job J Belmont Andrew S AS Guttman Mitchell M Leshyk Victor O VO Lis John T JT Lomvardas Stavros S Mirny Leonid A LA O'Shea Clodagh C CC Park Peter J PJ Ren Bing B Politz Joan C Ritland JCR Shendure Jay J Zhong Sheng S

Nature 20170901 7671

The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental techno ...[more]

PMID: 28905911

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