Ontology highlight
ABSTRACT:
SUBMITTER: Liso A
PROVIDER: S-EPMC5617388 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Liso Arcangelo A Castellani Stefano S Massenzio Francesca F Trotta Rosa R Pucciarini Alessandra A Bigerna Barbara B De Luca Pasquale P Zoppoli Pietro P Castiglione Filippo F Palumbo Maria Concetta MC Stracci Fabrizio F Landriscina Matteo M Specchia Giorgina G Bach Leon A LA Conese Massimo M Falini Brunangelo B
Oncotarget 20170601 37
Fever plays a role in activating innate immunity while its relevance in activating adaptive immunity is less clear. Even brief exposure to elevated temperatures significantly impacts on the immunostimulatory capacity of dendritic cells (DCs), but the consequences on immune response remain unclear. To address this issue, we analyzed the gene expression profiles of normal human monocyte-derived DCs from nine healthy adults subjected either to fever-like thermal conditions (39°C) or to normal tempe ...[more]