Genistein improves inflammatory response and colonic function through NF-?B signal in DSS-induced colonic injury.
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ABSTRACT:
SUBMITTER: Zhang R
PROVIDER: S-EPMC5617431 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
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Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury.
Zhang Rui R Xu Jian J Zhao Jian J Chen Yuzhe Y
Oncotarget 20170526 37
This study aimed to investigate the protective potential of genistein in dextran sulfate sodium (DSS)-induced colonic injury <i>in vitro</i> and <i>in vivo</i> models. The results showed that DSS exposure caused growth suppression, colonic injury, inflammation, and barrier dysfunction in mice. Dietary genistein alleviated DSS-caused colonic injury via reducing colonic weight, rectal bleeding, and diarrhea ratio. Meanwhile, genistein reduced colonic inflammatory response via downregulating cytoki ...[more]
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