Ontology highlight
ABSTRACT:
SUBMITTER: Bartolomeo R
PROVIDER: S-EPMC5617676 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Bartolomeo Rosa R Cinque Laura L De Leonibus Chiara C Forrester Alison A Salzano Anna Chiara AC Monfregola Jlenia J De Gennaro Emanuela E Nusco Edoardo E Azario Isabella I Lanzara Carmela C Serafini Marta M Levine Beth B Ballabio Andrea A Settembre Carmine C
The Journal of clinical investigation 20170905 10
The mammalian target of rapamycin complex 1 (mTORC1) kinase promotes cell growth by activating biosynthetic pathways and suppressing catabolic pathways, particularly that of macroautophagy. A prerequisite for mTORC1 activation is its translocation to the lysosomal surface. Deregulation of mTORC1 has been associated with the pathogenesis of several diseases, but its role in skeletal disorders is largely unknown. Here, we show that enhanced mTORC1 signaling arrests bone growth in lysosomal storage ...[more]