Membrane-Accelerated Amyloid-? Aggregation and Formation of Cross-? Sheets.
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ABSTRACT:
SUBMITTER: Khondker A
PROVIDER: S-EPMC5618134 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Membrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets.
Khondker Adree A Alsop Richard J RJ Rheinstädter Maikel C MC
Membranes 20170831 3
Amyloid- β aggregates play a causative role in Alzheimer's disease. These aggregates are a product of the physical environment provided by the basic neuronal membrane, composed of a lipid bilayer. The intrinsic properties of the lipid bilayer allow amyloid- β peptides to nucleate and form well-ordered cross- β sheets within the membrane. Here, we correlate the aggregation of the hydrophobic fragment of the amyloid- β protein, A β 25 - 35 , with the hydrophobicity, fluidity, and charge density of ...[more]
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