Ontology highlight
ABSTRACT:
SUBMITTER: Saruta J
PROVIDER: S-EPMC5618551 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Saruta Juri J To Masahiro M Sugimoto Masahiro M Yamamoto Yuko Y Shimizu Tomoko T Nakagawa Yusuke Y Inoue Hiroko H Saito Ichiro I Tsukinoki Keiichi K
International journal of molecular sciences 20170905 9
Brain-derived neurotrophic factor (BDNF) is abundant in the hippocampus and plays critical roles in memory and synapse formation, as well as exerting antidepressant-like effects in psychiatric disorders. We previously reported that BDNF is expressed in salivary glands and affects blood BDNF content. However, the function of salivary BDNF remains unclear. The aim of this study was to generate transgenic mice overexpressing BDNF in the salivary glands. Hence, we used the Lama construct (hemaggluti ...[more]