Ontology highlight
ABSTRACT:
SUBMITTER: Adler AJ
PROVIDER: S-EPMC5619014 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Adler Adam J AJ Mittal Payal P Ryan Joseph M JM Zhou Beiyan B Wasser Jeffrey S JS Vella Anthony T AT
Immunotherapy 20170101 1
Recent advances in cancer biology and genetics have fostered precision therapies targeting tumor-specific attributes. Immune-based therapies that elicit cytolytic T cells (CTL) specific for tumor antigens can provide therapeutic benefit to cancer patients, however, cure rates are typically low. This largely results from immunosuppressive mechanisms operating within the tumor microenvironment, many of which inflict metabolic stresses upon CTL. Conversely, immunotherapies can mitigate specific met ...[more]