Ontology highlight
ABSTRACT:
SUBMITTER: Larson CL
PROVIDER: S-EPMC5619019 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Larson Charles L CL Martinez Eric E Beare Paul A PA Jeffrey Brendan B Heinzen Robert A RA Bonazzi Matteo M
Future microbiology 20160715
Invasion of macrophages and replication within an acidic and degradative phagolysosome-like vacuole are essential for disease pathogenesis by Coxiella burnetii, the bacterial agent of human Q fever. Previous experimental constraints imposed by the obligate intracellular nature of Coxiella limited knowledge of pathogen strategies that promote infection. Fortunately, new genetic tools facilitated by axenic culture now allow allelic exchange and transposon mutagenesis approaches for virulence gene ...[more]