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Mesothelin as a target for chimeric antigen receptor-modified T cells as anticancer therapy.

ABSTRACT: Mesothelin is a promising target for immune-based therapy, specifically for mesothelioma and pancreatic and ovarian cancers that have high levels of mesothelin expression. Many preclinical and clinical studies that target tumors with high mesothelin expression with antibodies, immunotoxins, antibody-drug conjugates and vaccines have shown the potential of mesothelin as a target. Studies of T cells genetically modified with chimeric antigen receptors (CAR) report significant efficacy in hematologic malignancies, and antimesothelin CAR T cells are currently being investigated in clinical studies. Here we outline the rationale for using mesothelin as a target for immunotherapy, review the clinical and preclinical studies evaluating mesothelin-directed therapies and explore the promise of CAR T cells directed against mesothelin for immunotherapy in the future.

SUBMITTER: O'Hara M

PROVIDER: S-EPMC5619020 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Mesothelin as a target for chimeric antigen receptor-modified T cells as anticancer therapy.

O'Hara Mark M Stashwick Caitlin C Haas Andrew R AR Tanyi Janos L JL

Immunotherapy 20160101 4

Mesothelin is a promising target for immune-based therapy, specifically for mesothelioma and pancreatic and ovarian cancers that have high levels of mesothelin expression. Many preclinical and clinical studies that target tumors with high mesothelin expression with antibodies, immunotoxins, antibody-drug conjugates and vaccines have shown the potential of mesothelin as a target. Studies of T cells genetically modified with chimeric antigen receptors (CAR) report significant efficacy in hematolog ...[more]

PMID: 26973126

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Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer.

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Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers.

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