Ontology highlight
ABSTRACT:
SUBMITTER: O'Hara M
PROVIDER: S-EPMC5619020 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Immunotherapy 20160101 4
Mesothelin is a promising target for immune-based therapy, specifically for mesothelioma and pancreatic and ovarian cancers that have high levels of mesothelin expression. Many preclinical and clinical studies that target tumors with high mesothelin expression with antibodies, immunotoxins, antibody-drug conjugates and vaccines have shown the potential of mesothelin as a target. Studies of T cells genetically modified with chimeric antigen receptors (CAR) report significant efficacy in hematolog ...[more]