Behavioral and physiological consequences of enrichment loss in rats.
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ABSTRACT:
SUBMITTER: Smith BL
PROVIDER: S-EPMC5619656 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Behavioral and physiological consequences of enrichment loss in rats.
Smith Brittany L BL Lyons Carey E CE Correa Fernanda Guilhaume FG Benoit Stephen C SC Myers Brent B Solomon Matia B MB Herman James P JP
Psychoneuroendocrinology 20161202
Significant loss produces the highest degree of stress and compromised well-being in humans. Current rodent models of stress involve the application of physically or psychologically aversive stimuli, but do not address the concept of loss. We developed a rodent model for significant loss, involving removal of long-term access to a rewarding enriched environment. Our results indicate that removal from environmental enrichment produces a profound behavioral and physiological phenotype with depress ...[more]
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