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Behavioral and physiological consequences of enrichment loss in rats.


ABSTRACT: Significant loss produces the highest degree of stress and compromised well-being in humans. Current rodent models of stress involve the application of physically or psychologically aversive stimuli, but do not address the concept of loss. We developed a rodent model for significant loss, involving removal of long-term access to a rewarding enriched environment. Our results indicate that removal from environmental enrichment produces a profound behavioral and physiological phenotype with depression-like qualities, including helplessness behavior, hypothalamo-pituitary-adrenocortical axis dysregulation and overeating. Importantly, this enrichment removal phenotype was prevented by antidepressant treatment. Furthermore, the effects of enrichment removal do not occur following relief from chronic stress and are not duplicated by loss of exercise or social contact.

SUBMITTER: Smith BL 

PROVIDER: S-EPMC5619656 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Behavioral and physiological consequences of enrichment loss in rats.

Smith Brittany L BL   Lyons Carey E CE   Correa Fernanda Guilhaume FG   Benoit Stephen C SC   Myers Brent B   Solomon Matia B MB   Herman James P JP  

Psychoneuroendocrinology 20161202


Significant loss produces the highest degree of stress and compromised well-being in humans. Current rodent models of stress involve the application of physically or psychologically aversive stimuli, but do not address the concept of loss. We developed a rodent model for significant loss, involving removal of long-term access to a rewarding enriched environment. Our results indicate that removal from environmental enrichment produces a profound behavioral and physiological phenotype with depress  ...[more]

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