Ontology highlight
ABSTRACT:
SUBMITTER: Iwagami Y
PROVIDER: S-EPMC5619992 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Iwagami Yoshifumi Y Casulli Sarah S Nagaoka Katsuya K Kim Miran M Carlson Rolf I RI Ogawa Kosuke K Lebowitz Michael S MS Fuller Steve S Biswas Biswajit B Stewart Solomon S Dong Xiaoqun X Ghanbari Hossein H Wands Jack R JR
Heliyon 20170926 9
<h4>Background and aims</h4>Hepatocellular carcinoma (HCC) is a difficult to treat tumor with a poor prognosis. Aspartate β-hydroxylase (ASPH) is a highly conserved enzyme overexpressed on the cell surface of both murine and human HCC cells.<h4>Methods</h4>We evaluated therapeutic effects of nanoparticle lambda (λ) phage vaccine constructs against ASPH expressing murine liver tumors. Mice were immunized before and after subcutaneous implantation of a syngeneic BNL HCC cell line. Antitumor active ...[more]