Ontology highlight
ABSTRACT:
SUBMITTER: Lee DY
PROVIDER: S-EPMC5620285 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Oncotarget 20170802 40
Alzheimer's disease (AD) is one of the most common forms of dementia and is characterized by neuroinflammation and amyloidogenesis. Here we investigated the effects of KRICT-9 on neuroinflammation and amyloidogenesis in <i>in vitro</i> and <i>in vivo</i> AD models. We found that KRICT-9 decreased lipopolysaccharide (LPS)-induced inflammation in microglial BV-2 cells and astrocytes while reducing nitric oxide generation and expression of inflammatory marker proteins (iNOS and COX-2) as well as AP ...[more]