Ontology highlight
ABSTRACT:
SUBMITTER: Ren X
PROVIDER: S-EPMC5621167 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Ren Xiaojun X Deng Ruijie R Wang Lida L Zhang Kaixiang K Li Jinghong J
Chemical science 20170613 8
RNA splicing, which mainly involves two transesterification steps, is a fundamental process of gene expression and its abnormal regulation contributes to serious genetic diseases. Antisense oligonucleotides (ASOs) are genetic control tools that can be used to specifically control genes through alteration of the RNA splicing pathway. Despite intensive research, how ASOs or various other factors influence the multiple processes of RNA splicing still remains obscure. This is largely due to an inabi ...[more]