Ontology highlight
ABSTRACT:
SUBMITTER: Isoda T
PROVIDER: S-EPMC5621651 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Isoda Takeshi T Moore Amanda J AJ He Zhaoren Z Chandra Vivek V Aida Masatoshi M Denholtz Matthew M Piet van Hamburg Jan J Fisch Kathleen M KM Chang Aaron N AN Fahl Shawn P SP Wiest David L DL Murre Cornelis C
Cell 20170901 1
It is now established that Bcl11b specifies T cell fate. Here, we show that in developing T cells, the Bcl11b enhancer repositioned from the lamina to the nuclear interior. Our search for factors that relocalized the Bcl11b enhancer identified a non-coding RNA named ThymoD (thymocyte differentiation factor). ThymoD-deficient mice displayed a block at the onset of T cell development and developed lymphoid malignancies. We found that ThymoD transcription promoted demethylation at CTCF bound sites ...[more]