Ontology highlight
ABSTRACT:
SUBMITTER: Rhodes J
PROVIDER: S-EPMC5621834 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Rhodes James J Mazza Davide D Nasmyth Kim K Uphoff Stephan S
eLife 20170915
The cohesin complex mediates DNA-DNA interactions both between (sister chromatid cohesion) and within chromosomes (DNA looping). It has been suggested that intra-chromosome loops are generated by extrusion of DNAs through the lumen of cohesin's ring. Scc2 (Nipbl) stimulates cohesin's ABC-like ATPase and is essential for loading cohesin onto chromosomes. However, it is possible that the stimulation of cohesin's ATPase by Scc2 also has a post-loading function, for example driving loop extrusion. U ...[more]