Ontology highlight
ABSTRACT:
SUBMITTER: Snir O
PROVIDER: S-EPMC5621872 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
JCI insight 20170907 17
The role of B cells and posttranslational modifications in pathogenesis of organ-specific immune diseases is increasingly envisioned but remains poorly understood, particularly in human disorders. In celiac disease, transglutaminase 2-modified (TG2-modified; deamidated) gluten peptides drive disease-specific T cell and B cell responses, and antibodies to deamidated gluten peptides are excellent diagnostic markers. Here, we substantiate by high-throughput sequencing of IGHV genes that antibodies ...[more]