Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC5622187 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Liu Jianhua J Sui Hua H Zhao Jianlin J Wang Yan Y
Frontiers in physiology 20170925
<b>Objective:</b> This study aimed to investigate the effect of osmotin on myocardial ischemia/reperfusion (I/R), as well as the underlying mechanisms. <b>Methods:</b><i>In vitro</i> I/R injury model was established on rat cardiac myoblast H9c2 cells by oxygen and glucose deprivation followed by reperfusion (OGD/R). Cells were administrated with osmotin, and transfected with small interfering RNAs (siRNAs) which specifically target adiponectin receptor 1 or 2 (AdipoR1/2). Besides, the cells were ...[more]