Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC5622307 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Zhou Yebin Y Chen Bo B Mittereder Nanette N Chaerkady Raghothama R Strain Martin M An Ling-Ling LL Rahman Saifur S Ma Wenting W Low Choon Pei CP Chan Denice D Neal Frances F Bingham Clifton O CO Sampson Kevon K Darrah Erika E Siegel Richard M RM Hasni Sarfaraz S Andrade Felipe F Vousden Katherine A KA Mustelin Tomas T Sims Gary P GP
Frontiers in immunology 20170925
Autoantibodies directed against citrullinated epitopes of proteins are highly diagnostic of rheumatoid arthritis (RA), and elevated levels of protein citrullination can be found in the joints of patients with RA. Calcium-dependent peptidyl-arginine deiminases (PAD) are the enzymes responsible for citrullination. PAD2 and PAD4 are enriched in neutrophils and likely drive citrullination under inflammatory conditions. PADs may be released during NETosis or cell death, but the mechanisms responsible ...[more]