Ontology highlight
ABSTRACT:
SUBMITTER: Castan A
PROVIDER: S-EPMC5622318 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Castán Alicia A Hernández Pablo P Krimer Dora B DB Schvartzman Jorge B JB
Nucleic acids research 20170901 17
In eukaryotes, ribosomal genes (rDNA) are organized in tandem repeats localized in one or a few clusters. Each repeat encompasses a transcription unit and a non-transcribed spacer. Replication forks moving in the direction opposite to transcription are blocked at specific sites called replication fork barriers (rRFBs) in the non-transcribed spacer close to the 3' end of the transcription unit. Here, we investigated and quantified the efficiency of rRFBs in Saccharomyces cerevisiae and to this en ...[more]