Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC5622322 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Chen Jin J Tang Qingnan Q Guo Shiwen S Lu Chen C Le Shimin S Yan Jie J
Nucleic acids research 20170901 17
The interaction between the single-stranded DNA and the homologous duplex DNA is essential for DNA homologous repair. Here, we report that parallel triplex structure can form spontaneously between a mechanically extended ssDNA and a homologous dsDNA in protein-free condition. The triplex has a contour length close to that of a B-form DNA duplex and remains stable after force is released. The binding energy between the ssDNA and the homologous dsDNA in the triplex is estimated to be comparable to ...[more]