Ontology highlight
ABSTRACT:
SUBMITTER: Marin V
PROVIDER: S-EPMC5622766 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Marin Veronica V Gazzin Silvia S Gambaro Sabrina E SE Dal Ben Matteo M Calligaris Sonia S Anese Monica M Raseni Alan A Avellini Claudio C Giraudi Pablo J PJ Tiribelli Claudio C Rosso Natalia N
Nutrients 20170912 9
The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in adolescents is challenging the global care system. No therapeutic strategies have been defined so far, and changes in the lifestyle remain the only alternative. In this study, we assessed the protective effects of silymarin in a juvenile non-alcoholic steatohepatitis (NASH) model and the in vitro effects on fat-laden human hepatocytes. C57Bl/6 mice were exposed to HFHC diet immediately after weaning. After eight weeks, ani ...[more]