Ontology highlight
ABSTRACT:
SUBMITTER: Watson GM
PROVIDER: S-EPMC5623053 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Watson Gabrielle M GM Lucas William A H WAH Gunzburg Menachem J MJ Wilce Jacqueline A JA
Frontiers in molecular biosciences 20170926
Growth factor receptor bound protein 7 (Grb7) is an adaptor protein with established roles in the progression of both breast and pancreatic cancers. Through its C-terminal SH2 domain, Grb7 binds to phosphorylated tyrosine kinases to promote proliferative and migratory signaling. Here, we investigated the molecular basis for the specificity of a Grb7 SH2-domain targeted peptide inhibitor. We identified that arginine 462 in the BC loop is unique to Grb7 compared to Grb2, another SH2 domain bearing ...[more]