Ontology highlight
ABSTRACT:
SUBMITTER: Minniti E
PROVIDER: S-EPMC5623067 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Minniti Elirosa E Byl Jo Ann W JAW Riccardi Laura L Sissi Claudia C Rosini Michela M De Vivo Marco M Minarini Anna A Osheroff Neil N
Bioorganic & medicinal chemistry letters 20170908 20
It has been proposed that xanthone derivatives with anticancer potential act as topoisomerase II inhibitors because they interfere with the ability of the enzyme to bind its ATP cofactor. In order to further characterize xanthone mechanism and generate compounds with potential as anticancer drugs, we synthesized a series of derivatives in which position 3 was substituted with different polyamine chains. As determined by DNA relaxation and decatenation assays, the resulting compounds are potent t ...[more]