Ontology highlight
ABSTRACT:
SUBMITTER: Cohen JA
PROVIDER: S-EPMC5623598 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Cohen Jeffrey A JA Imrey Peter B PB Planchon Sarah M SM Bermel Robert A RA Fisher Elizabeth E Fox Robert J RJ Bar-Or Amit A Sharp Susan L SL Skaramagas Thomai T TT Jagodnik Patricia P Karafa Matt M Morrison Shannon S Reese Koc Jane J Gerson Stanton L SL Lazarus Hillard M HM
Multiple sclerosis (Houndmills, Basingstoke, England) 20170406 4
<h4>Background</h4>Mesenchymal stem cells (MSCs) exhibit immunomodulatory, tissue-protective, and repair-promoting properties in vitro and in animals. Clinical trials in several human conditions support the safety and efficacy of MSC transplantation. Published experience in multiple sclerosis (MS) is modest.<h4>Objective</h4>To assess feasibility, safety, and tolerability and explore efficacy of autologous MSC transplantation in MS.<h4>Methods</h4>Participants with relapsing-remitting multiple s ...[more]