Ontology highlight
ABSTRACT:
SUBMITTER: Postler TS
PROVIDER: S-EPMC5623643 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Postler Thomas S TS Pantry Shara N SN Desrosiers Ronald C RC Ghosh Sankar S
Virology 20170810
Long non-coding RNAs (lncRNAs) are rapidly emerging as important regulators of a diverse array of cellular functions. Here, we describe a meta-analysis of two independent RNA-seq studies to identify lncRNAs that are differentially expressed upon HIV-1 infection. Only three lncRNA genes exhibited altered expression of ≥ 2-fold in HIV-1-infected cells. Of these, the uncharacterized lncRNA LINC00173 was chosen for further study. Both transcript variants of LINC00173 (lnc173 TSV1 and 2) could be det ...[more]