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Sex Differences in rt-PA Utilization at Hospitals Treating Stroke: The National Inpatient Sample.


ABSTRACT:

Background and purpose

Sex and race disparities in recombinant tissue plasminogen activator (rt-PA) use have been reported. We sought to explore sex and race differences in the utilization of rt-PA at primary stroke centers (PSCs) compared to non-PSCs across the US.

Methods

Data from the National (Nationwide) Inpatient Sample (NIS) 2004-2010 was utilized to assess sex differences in treatment for ischemic stroke in PSCs compared to non-PSCs.

Results

There were 304,152 hospitalizations with a primary diagnosis of ischemic stroke between 2004 and 2010 in the analysis: 75,160 (24.7%) patients were evaluated at a PSC. A little over half of the patients evaluated at PSCs were female (53.8%). A lower proportion of women than men received rt-PA at both PSCs (6.8 vs. 7.5%, p?p?p-value for interaction?=?0.58).

Conclusion

Women are less likely to receive rt-PA than men at both PSCs and non-PSCs. Absolute treatment rates are lowest in black women, although the relative difference in men and women was greatest for white women.

SUBMITTER: Boehme AK 

PROVIDER: S-EPMC5623663 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Sex Differences in rt-PA Utilization at Hospitals Treating Stroke: The National Inpatient Sample.

Boehme Amelia K AK   Carr Brendan G BG   Kasner Scott Eric SE   Albright Karen C KC   Kallan Michael J MJ   Elkind Mitchell S V MSV   Branas Charles C CC   Mullen Michael T MT  

Frontiers in neurology 20170927


<h4>Background and purpose</h4>Sex and race disparities in recombinant tissue plasminogen activator (rt-PA) use have been reported. We sought to explore sex and race differences in the utilization of rt-PA at primary stroke centers (PSCs) compared to non-PSCs across the US.<h4>Methods</h4>Data from the National (Nationwide) Inpatient Sample (NIS) 2004-2010 was utilized to assess sex differences in treatment for ischemic stroke in PSCs compared to non-PSCs.<h4>Results</h4>There were 304,152 hospi  ...[more]

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