LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination.
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ABSTRACT:
SUBMITTER: Sun D
PROVIDER: S-EPMC5623836 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination.
Sun Dingya D Yu Zhongwang Z Fang Xue X Liu Mingdong M Pu Yingyan Y Shao Qi Q Wang Dan D Zhao Xiaolin X Huang Aijun A Xiang Zhenghua Z Zhao Chao C Franklin Robin Jm RJ Cao Li L He Cheng C
EMBO reports 20170814 10
The regulation of inflammation is pivotal for preventing the development or reoccurrence of multiple sclerosis (MS). A biased ratio of high-M1 versus low-M2 polarized microglia is a major pathological feature of MS Here, using microarray screening, we identify the long noncoding RNA (lncRNA) GAS5 as an epigenetic regulator of microglial polarization. Gain- and loss-of-function studies reveal that GAS5 suppresses microglial M2 polarization. Interference with GAS5 in transplanted microglia attenua ...[more]
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