Ontology highlight
ABSTRACT:
SUBMITTER: Oppikofer M
PROVIDER: S-EPMC5623870 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Oppikofer Mariano M Bai Tianyi T Gan Yutian Y Haley Benjamin B Liu Peter P Sandoval Wendy W Ciferri Claudio C Cochran Andrea G AG
EMBO reports 20170811 10
ISWI chromatin remodelers mobilize nucleosomes to control DNA accessibility. Complexes isolated to date pair one of six regulatory subunits with one of two highly similar ATPases. However, we find that each endogenously expressed ATPase co-purifies with every regulatory subunit, substantially increasing the diversity of ISWI complexes, and we additionally identify BAZ2B as a novel, seventh regulatory subunit. Through reconstitution of catalytically active human ISWI complexes, we demonstrate tha ...[more]