Ontology highlight
ABSTRACT:
SUBMITTER: Feng W
PROVIDER: S-EPMC5625114 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Frontiers in molecular neuroscience 20170928
CHD7 (Chromo-Helicase-DNA binding protein 7) protein is an ATP-dependent chromatin remodeler. Heterozygous mutation of the <i>CHD7</i> gene causes a severe congenital disease known as CHARGE syndrome. Most CHARGE syndrome patients have brain structural anomalies, implicating an important role of CHD7 during brain development. In this review, we summarize studies dissecting developmental functions of CHD7 in the brain and discuss pathogenic mechanisms behind neurodevelopmental defects caused by m ...[more]