Ontology highlight
ABSTRACT:
SUBMITTER: Choudhury AR
PROVIDER: S-EPMC5625255 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Choudhury Abhijnan Ray AR Manna Madhu Sudan MS Mukherjee Santanu S
Chemical science 20170802 9
A formal <i>umpolung</i> strategy is presented for the enantioselective installation of an alkenyl group with a terminal double bond at a tertiary center. This one-pot two-step sequence relies on the unique features of the nitro group, which after inverting the polarity of the alkenylating agent toward the desired bond formation, itself serves as a leaving group. The application of this protocol to cyclic β-ketoesters results in densely functionalized products, bearing an all-carbon quaternary s ...[more]