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Ten-year trends in antiretroviral therapy persistence among US Medicaid beneficiaries.


ABSTRACT: OBJECTIVE:Whether the rate of HIV antiretroviral therapy (ART) persistence has improved over time in the United States is unknown. We examined ART persistence trends between 2001 and 2010, using non-HIV medications as a comparator. METHODS:We conducted a retrospective cohort study using Medicaid claims. We defined persistence as the duration of treatment from the first to the last fill date before a 90-day permissible gap and used Kaplan-Meier curves and Cox proportional hazard models to assess crude and adjusted nonpersistence. The secular trends of ART persistence in 43?598 HIV patients were compared with the secular trends of persistence with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers (ACEI/ARB), statins, and metformin in non-HIV-infected patients and subgroups of HIV patients who started these control medications while using ART. RESULTS:Median time to ART nonpersistence increased from 23.9 months in 2001-2003 to 35.4 months in 2004-2006 and was not reached for those starting ART in 2007-2010. In adjusted models, ART initiators in 2007-2010 had 11% decreased hazard of nonpersistence compared with those who initiated in 2001-2003 (P?

SUBMITTER: Youn B 

PROVIDER: S-EPMC5625296 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Ten-year trends in antiretroviral therapy persistence among US Medicaid beneficiaries.

Youn Bora B   Shireman Theresa I TI   Lee Yoojin Y   Galárraga Omar O   Rana Aadia I AI   Justice Amy C AC   Wilson Ira B IB  

AIDS (London, England) 20170701 12


<h4>Objective</h4>Whether the rate of HIV antiretroviral therapy (ART) persistence has improved over time in the United States is unknown. We examined ART persistence trends between 2001 and 2010, using non-HIV medications as a comparator.<h4>Methods</h4>We conducted a retrospective cohort study using Medicaid claims. We defined persistence as the duration of treatment from the first to the last fill date before a 90-day permissible gap and used Kaplan-Meier curves and Cox proportional hazard mo  ...[more]

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