Monoclonal Antibodies against Zika Virus: Therapeutics and Their Implications for Vaccine Design.
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ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC5625485 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Monoclonal Antibodies against Zika Virus: Therapeutics and Their Implications for Vaccine Design.
Wang Qihui Q Yan Jinghua J Gao George Fu GF
Journal of virology 20170927 20
Zika virus (ZIKV) has caused global concern due to its association with neurological complications in newborns and adults. Although no vaccines or antivirals against ZIKV infection have been approved to date, hundreds of monoclonal antibodies (MAbs) have been developed in a short period. Here, we first present a complete picture of the ZIKV MAbs and then focus on the neutralizing mechanisms and immune hot spots uncovered through structural studies, which provide insight for therapeutics and vacc ...[more]
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