Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition.
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ABSTRACT:
SUBMITTER: Won S
PROVIDER: S-EPMC5625543 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition.
Won Sangho S Richards Sarah-Jane SJ Walker Marc M Gibson Matthew I MI
Nanoscale horizons 20161214 2
Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric 'gates' to enable external control (<i>via</i> temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition. ...[more]
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