Growth and Nutritional Biomarkers of Preterm Infants Fed a New Powdered Human Milk Fortifier: A Randomized Trial.

ABSTRACT: OBJECTIVES:The aim of this study was to assess growth and nutritional biomarkers of preterm infants fed human milk (HM) supplemented with a new powdered HM fortifier (nHMF) or a control HM fortifier (cHMF). The nHMF provides similar energy content, 16% more protein (partially hydrolyzed whey), and higher micronutrient levels than the cHMF, along with medium-chain triglycerides and docosahexaenoic acid. METHODS:In this controlled, multicenter, double-blind study, a sample of preterm infants ?32 weeks or ?1500?g were randomized to receive nHMF (n?=?77) or cHMF (n?=?76) for a minimum of 21 days. Weight gain was evaluated for noninferiority (margin?=?-1?g/day) and superiority (margin?=?0?g/day). Nutritional status and gut inflammation were assessed by blood, urine, and fecal biochemistries. Adverse events were monitored. RESULTS:Adjusted mean weight gain (analysis of covariance) was 2.3?g/day greater in nHMF versus cHMF; the lower limit of the 95% CI (0.4?g/day) exceeded both noninferiority (P?

SUBMITTER: Rigo J 

PROVIDER: S-EPMC5625962 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature