Ontology highlight
ABSTRACT:
SUBMITTER: Villarino AV
PROVIDER: S-EPMC5626390 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Villarino Alejandro V AV Sciumè Giuseppe G Davis Fred P FP Iwata Shigeru S Zitti Beatrice B Robinson Gertraud W GW Hennighausen Lothar L Kanno Yuka Y O'Shea John J JJ
The Journal of experimental medicine 20170915 10
Innate lymphoid cells (ILCs) patrol environmental interfaces to defend against infection and protect barrier integrity. Using a genetic tuning model, we demonstrate that the signal-dependent transcription factor (TF) STAT5 is critical for accumulation of all known ILC subsets in mice and reveal a hierarchy of STAT5 dependency for populating lymphoid and nonlymphoid tissues. We apply transcriptome and genomic distribution analyses to define a STAT5 gene signature in natural killer (NK) cells, the ...[more]