Ontology highlight
ABSTRACT:
SUBMITTER: Gowrishankar S
PROVIDER: S-EPMC5626538 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Gowrishankar Swetha S Wu Yumei Y Ferguson Shawn M SM
The Journal of cell biology 20170807 10
Lysosomes robustly accumulate within axonal swellings at Alzheimer's disease (AD) amyloid plaques. However, the underlying mechanisms and disease relevance of such lysosome accumulations are not well understood. Motivated by these problems, we identified JNK-interacting protein 3 (JIP3) as an important regulator of axonal lysosome transport and maturation. JIP3 knockout mouse neuron primary cultures accumulate lysosomes within focal axonal swellings that resemble the dystrophic axons at amyloid ...[more]