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Olfactory Functioning and Depression: A Systematic Review.


ABSTRACT: BACKGROUND:Research has demonstrated a reduction in olfactory functioning in patients with schizophrenia. This research has led to examination of olfactory functioning in other mental disorders, such as depression. There is a great deal of variation in the results generated from such research, and it remains unclear as to how olfactory functioning is associated with or impacted by depression. METHOD:The current review examined the literature in accordance with PRISMA guidelines in order to generate a better understanding of this relationship and to identify if and what aspects of olfactory processing are altered. Through examination of the available literature from the databases PubMed, Ovid Medline, CINAL, and PsychINFO, 15 manuscripts were selected to determine if there was a difference in olfactory processing-specifically central and peripheral processing-between depressed individuals and non-depressed controls. RESULTS:The comparison of the 15 studies showed that the majority of studies (9/15, 60%) found a difference in overall olfactory functioning between depressed individuals and non-depressed controls (p?

SUBMITTER: Taalman H 

PROVIDER: S-EPMC5627007 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Olfactory Functioning and Depression: A Systematic Review.

Taalman Hannah H   Wallace Caroline C   Milev Roumen R  

Frontiers in psychiatry 20170928


<h4>Background</h4>Research has demonstrated a reduction in olfactory functioning in patients with schizophrenia. This research has led to examination of olfactory functioning in other mental disorders, such as depression. There is a great deal of variation in the results generated from such research, and it remains unclear as to how olfactory functioning is associated with or impacted by depression.<h4>Method</h4>The current review examined the literature in accordance with PRISMA guidelines in  ...[more]

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