Ontology highlight
ABSTRACT:
SUBMITTER: Kim HL
PROVIDER: S-EPMC5627035 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Kim Hye-Lin HL Jung Yunu Y Park Jinbong J Youn Dong-Hyun DH Kang JongWook J Lim Seona S Lee Beom Su BS Jeong Mi-Young MY Choe Seong-Kyu SK Park Raekil R Ahn Kwang Seok KS Um Jae-Young JY
Frontiers in pharmacology 20170920
Brown adipocytes dissipate energy as heat and hence have an important therapeutic capacity for obesity. Development of brown-like adipocytes (also called beige) is also another attractive target for obesity treatment. Here, we investigated the effect of farnesol, an isoprenoid, on adipogenesis in adipocytes and on the browning of white adipose tissue (WAT) as well as on the weight gain of high-fat diet (HFD)-induced obese mice. Farnesol inhibited adipogenesis and the related key regulators inclu ...[more]