Ontology highlight
ABSTRACT:
SUBMITTER: Monteleone S
PROVIDER: S-EPMC5627182 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Biophysical journal 20171001 7
Mutations of positively charged amino acids in the S4 transmembrane segment of a voltage-gated ion channel form ion-conducting pathways through the voltage-sensing domain, named ω-current. Here, we used structure modeling and MD simulations to predict pathogenic ω-currents in Ca<sub>V</sub>1.1 and Ca<sub>V</sub>1.3 Ca<sup>2+</sup> channels bearing several S4 charge mutations. Our modeling predicts that mutations of Ca<sub>V</sub>1.1-R1 (R528H/G, R897S) or Ca<sub>V</sub>1.1-R2 (R900S, R1239H) lin ...[more]