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A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies.


ABSTRACT: Influenza viruses evade human adaptive immune responses due to continuing antigenic changes. This makes it necessary to re-formulate and re-administer current seasonal influenza vaccines on an annual basis. Our pan-influenza vaccination approach attempts to redirect antibody responses from the variable, immuno-dominant hemagglutinin head towards the conserved-but immuno-subdominant-hemagglutinin stalk. The strategy utilizes sequential immunization with chimeric hemagglutinin-based vaccines expressing exotic head domains, and a conserved hemagglutinin stalk. We compared a live-attenuated influenza virus prime followed by an inactivated split-virus boost to two doses of split-virus vaccines and assessed the impact of adjuvant on protection against challenge with pandemic H1N1 virus in ferrets. All tested immunization regimens successfully induced broadly cross-reactive antibody responses. The combined live-attenuated/split virus vaccination conferred superior protection against pandemic H1N1 infection compared to two doses of split-virus vaccination. Our data support advancement of this chimeric hemagglutinin-based vaccine approach to clinical trials in humans.

SUBMITTER: Nachbagauer R 

PROVIDER: S-EPMC5627297 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies.

Nachbagauer Raffael R   Liu Wen-Chun WC   Choi Angela A   Wohlbold Teddy John TJ   Atlas Talia T   Rajendran Madhusudan M   Solórzano Alicia A   Berlanda-Scorza Francesco F   García-Sastre Adolfo A   Palese Peter P   Albrecht Randy A RA   Krammer Florian F  

NPJ vaccines 20170914


Influenza viruses evade human adaptive immune responses due to continuing antigenic changes. This makes it necessary to re-formulate and re-administer current seasonal influenza vaccines on an annual basis. Our pan-influenza vaccination approach attempts to redirect antibody responses from the variable, immuno-dominant hemagglutinin head towards the conserved-but immuno-subdominant-hemagglutinin stalk. The strategy utilizes sequential immunization with chimeric hemagglutinin-based vaccines expre  ...[more]

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