Ontology highlight
ABSTRACT:
SUBMITTER: Nachbagauer R
PROVIDER: S-EPMC5627297 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Nachbagauer Raffael R Liu Wen-Chun WC Choi Angela A Wohlbold Teddy John TJ Atlas Talia T Rajendran Madhusudan M Solórzano Alicia A Berlanda-Scorza Francesco F García-Sastre Adolfo A Palese Peter P Albrecht Randy A RA Krammer Florian F
NPJ vaccines 20170914
Influenza viruses evade human adaptive immune responses due to continuing antigenic changes. This makes it necessary to re-formulate and re-administer current seasonal influenza vaccines on an annual basis. Our pan-influenza vaccination approach attempts to redirect antibody responses from the variable, immuno-dominant hemagglutinin head towards the conserved-but immuno-subdominant-hemagglutinin stalk. The strategy utilizes sequential immunization with chimeric hemagglutinin-based vaccines expre ...[more]