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ABSTRACT:
SUBMITTER: Losdorfer Bozic A
PROVIDER: S-EPMC5627345 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Lošdorfer Božič Anže A Podgornik Rudolf R
Biophysical journal 20171001 7
Electrostatic interactions play a fundamental role in the structure and function of proteins. Due to ionizable amino acid residues present on the solvent-exposed surfaces of proteins, the protein charge is not constant but varies with the changes in the environment-most notably, the pH of the surrounding solution. We study the effects of pH on the charge of four globular proteins by expanding their surface charge distributions in terms of multipoles. The detailed representation of the charges on ...[more]