Ontology highlight
ABSTRACT:
SUBMITTER: Bakre AA
PROVIDER: S-EPMC5627394 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Bakre Abhijeet A AA Shim Byoung-Shik BS Tripp Ralph A RA
Scientific reports 20171004 1
Global poliovirus eradication efforts include high vaccination coverage with live oral polio vaccine (OPV), surveillance for acute flaccid paralysis, and OPV "mop-up" campaigns. An important objective involves host-directed strategies to reduce PV replication to diminish viral shedding in OPV recipients. In this study, we show that microRNA-134-5p (miR-134) can regulate Sabin-1 replication but not Sabin-2 or Sabin-3 via direct interaction with the PV 5'UTR. Hypochromicity data showed miR-134 bin ...[more]